Name | YTTERBIUM(III) PERCHLORATE |
Synonyms | YTTERBIUM PERCHLORATE ytterbium(3+) perchlorate YTTERBIUM(III) PERCHLORATE ytterbium(3+),triperchlorate |
CAS | 13498-08-3 |
EINECS | 236-823-9 |
Molecular Formula | Cl3O12Yb |
Molar Mass | 471.39 |
Density | 1.474g/mLat 25°C |
Water Solubility | Insoluble in water. |
Vapor Presure | 0.12 psi ( 20 °C) |
Appearance | liquid |
Color | colorless |
Risk Codes | R8 - Contact with combustible material may cause fire R34 - Causes burns |
Safety Description | S17 - Keep away from combustible material. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
UN IDs | UN 3211 5.1/PG 2 |
Hazard Class | 5.1 |
Packing Group | II |
Use | ytterbium perchlorate, also known as ytterbium perchlorate, is a rare earth perchloric acid compound. Ytterbium perchlorate on rat dorsal root neurons cytotoxicity and membrane potassium channels have a greater impact. It has been reported that it can be used to prepare a rare Earth Organic light conversion agent. |
Study on pharmacological activity | du Zhengqing et al. studied ytterbium perchlorate (Yb(ClO4)3) to induce the apoptosis of rat dorsal root nerve (DRG), induce the change of intracellular calcium concentration and the effect on the potassium ion channel on the membrane. DRG cells were treated with different concentrations of Yb(ClO4)3 for 24 and 96H, cell apoptosis and intracellular calcium fluorescence intensity were detected. The effects of Yb(ClO4)3 on different potassium channel currents in cell membrane were recorded by whole cell patch clamp method. The results showed that DRG neurons treated with 10, 1000, μmol/LYb(ClO4)3 for 24h showed no apoptosis, cell apoptosis (P<0.05~0.01), especially 1000 μmol/LYb (ClO4)3, the apoptosis rate reached (55.23±3.76)%(P<0.01). The fluorescence intensity of Ca2 + in DRG neurons incubated with Yb(ClO4)3 was significantly increased; Yb(ClO4)3 inhibited the growth of dorsal root ganglion fibers and neuronal processes. Yb(ClO4)3 inhibits the potassium current on the membrane of DRG neurons, and the intracellular and extracellular Yb(ClO4)3 acts at different sites of potassium channels. Yb(ClO4)3 in the extracellular fluid blocked the transient outward potassium current IA in different degrees, but had little effect on the delayed rectifier potassium current; adding the same concentration of Yb(ClO4)3 to the electrode inner liquid has little effect on IA, but specifically blocks the delayed rectifier potassium current IK. 10 μmol/LYb(ClO4)3 significantly shifted the activation and inactivation processes of IA to the right, extending the time for the transient outward potassium current to reach the peak and the time constant for rapid inactivation, increases the excitability of neurons. |